Nakamura M, Nishiwaki Y, Ushida T, Toyama Y. Investigating novel molecular regulatory markers like circRNAs could clarify the underlying molecular mechanisms of IDD. The controversy concerning the association between IDD and environmental and clinical factors necessitates in-depth population research. Temperature, heavy metal exposure, age, overweight, occupation, exercise, hypertension, and smoking were the environmental and clinical factors associated with IDD progression.Ĭonclusion: Although the results need confirmation by experimental analysis, they reflect the possible role of particular circRNAs in IDD pathogenesis. The upshots indicated that these ۲ circular circRNAs might sponge hsa-miR-۳۳۰-۳p, hsa-miR-۵۰۲-۵p, hsa-miR-۶۶۲, hsa-miR-۸۷۴, and hsa-miR-۶۴۶ and regulate PSD۳, SIK۲, PCYT۱B, ARID۵B, MTMR۳, and HIPK۲ expressions, which play significant roles Sites for AGO۲ and EIF۴A۳ and several microRNAs. The functional in silico analysis showed that the aforementioned circRNAs harbored target Two circRNAs (hsa_circRNA_۱۰۱۶۴۵ and hsa_circRNA_۱۰۱۸۵۲) exhibited the most downregulated and upregulated expressions. Results: Twenty-five circRNAs were differentially expressed in IDD. Environmental and clinical factors were reviewed through PubMed and Google Scholar. Functional in silico analysis was done on circRNAs with the highest differential expression. GEO۲R was employed to analyze the expression profiles of the circRNAs. Methods: The circRNA array profiling of patients with IDD and healthy individuals (GSE۶۷۵۶۶) was acquired from Gene Expression Omnibus (GEO). Additionally, the environmental and clinical factors involved in IDD pathogenesis were reviewed. 
This study aimed to determine differentially expressed circular RNAs (circRNAs) in IDD by bioinformatics. The underlying pathogenesis of IDD needs elucidation. Background: Intervertebral disc degeneration (IDD) is a common disability in the working-age population.
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